Name	HY-Lysostaphin
CAS	9011-93-2
MW	≈27.0KDa
Source	Recombinant expression in E.coli
Protein purity	＞98%（SDS-PAGE detection）
Product application	Biological bacteriostatic agent; Disinfectant, medical device development. etc.

Lysostaphin is a peptidase produced by Staphylococcus simulans and was separated in 1960 by Schindler and Schuhardt. Lysostaphin is synthesized as a preproenzyme of 42,000 Da with a signal peptide that is cleaved intracellularly and an N-terminal propeptide removed extracellularly to yield the mature 27-kDa enzyme. The sequence element that is responsible for binding to the cell wall of Staphylococcus aureus is at the C-terminus of the molecule .

Lysostaphin cleaves staphylococcal peptidoglycans in general but is directed specifically to S.aureus target cells. In lysing staphylococci, the key enzymatic reaction of lysostaphin is the specific cleavage of the Gly-Gly bond in the pentaglycine subunit of the cell wall peptidoglycan and lyses cells in all metabolic states .